We initiated real-time nationwide anti—SARS-CoV-2 seroprevalence surveying of blood donations as a tool in monitoring the epidemic. The infection fatality rate was estimated to be slightly lower than previously reported from other countries not using seroprevalence data. These VTs were still circulating among all age groups. We observed serotype replacement in young children due mainly to increased nontypeable pneumococci. The cost-effectiveness of targeted testing and treatment for latent tuberculosis infection varies across states but was greatest among people living with HIV; moderate among people who are non—US-born, incarcerated, or homeless; and least cost-effective among people living with diabetes. Cell-free DNA derived from B.
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