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Pharmacokinetics analysis

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Pharmacokinetics PK is the branch of pharmacology exploring the effects of the body on a drug. In particular, PK helps us to understand in a quantitative way how a drug moves into, passes through, and is eventually cleared from the body. Compartmental methods consider the body to consist of a finite number of interconnected, well-mixed, and kinetically homogeneous compartments e. Based upon this view, the pharmacokineticist makes certain assumptions and develops models based upon nonlinear regression analysis to describe the PK of the drug. As a result of this approach, there is the potential for variability in the output of the analysis from one analyst to another, since the assumptions used to build the PK model may be somewhat different.

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What is Noncompartmental PK Analysis?

Noncompartmental vs. Compartmental PK Analysis

Reducing the dose of efavirenz can improve safety, reduce costs, and increase access for patients with HIV infection. We developed a mechanistic population pharmacokinetic model using pooled data from women included in seven studies samples, collected during pregnancy. It was predicted that reduced-dose efavirenz provides adequate exposure during pregnancy. These findings warrant prospective confirmation.

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Pharmacokinetic—Pharmacodynamic (PKPD) Analysis with Drug Discrimination

Pharmacokinetics PK Studies determine drug behavior in the human body and facilitate critical decision making on drug dosage and safety. We generate and model your PK sample analysis data using a fully validated bioanalytical assay to evaluate relevant PK parameters such as bioavailability, distribution, metabolism, and clearance, etc. NorthEast BioLab offers topnotch PK assay sample analysis and reporting to de-risk your drug development and regulatory submission. How can we help with your Pharmacokinetics PK Study needs? A pharmacokinetic study provides the basis for determining drug exposures in the body over time.

Pharmacokinetics from Ancient Greek pharmakon "drug" and kinetikos "moving, putting in motion"; see chemical kinetics , sometimes abbreviated as PK , is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs , pesticides , food additives , cosmetics , etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body.